Lopez Cisneros, Carmen Lucia published the artcileStudy of a Selected Series of 3- and 4-Arylcoumarins as Antifungal Agents against Dermatophytic Fungi: T. rubrum and T. mentagrophytes, Formula: C8H7NO4, the publication is ChemistrySelect (2021), 6(37), 9981-9989, database is CAplus.
The main etiol. agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagrophytes). A new series of twenty-three 3- and 4-arylcoumarins was synthesized and the antifungal activities against clin. isolates of T. rubrum and T. mentagrophytes were evaluated. Sixteen out of twenty-three mols. exhibited antifungal activity against one or both fungi strains. In some cases, the activity against T. rubrum has been comparable to fluconazole, one of the standards, being 8-methoxy-3-(4¡ä-nitrophenyl)coumarin (16) the best compound within this series (min. inhibitory concentration, MIC=6.25 ¦¬g/mL). The preliminary structure-activity relationship study showed that the antifungal activity depends on the position and nature of the substitution patterns. The cytotoxicity of eleven compounds on D-384 (astrocytoma), A-549 (lung cancer) and RKO (colorectal cancer) cell lines was also performed. With the aim of deeply understand the potential of these mols. as hits to develop new drugs, the theor. absorption, distribution, metabolism and excretion (ADME) properties of the active compounds were calculated
ChemistrySelect published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Formula: C8H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia