Roubinet, Benoit published the artcileA Synthetic Route to 3-(Heteroaryl)-7-hydroxycoumarins Designed for Biosensing Applications, Category: catalysis-chemistry, the publication is European Journal of Organic Chemistry (2015), 2015(1), 166-182, database is CAplus.
A straightforward method to synthesize 3-(2-benzimidazolyl)-7-hydroxycoumarins, based on a condensation reaction of 7-acetoxy-3-(formyl)coumarin with various C- and/or N-substituted ortho-phenylenediamine derivatives is presented. This unusual approach proved particularly effective for introducing different hydrophilic groups (carboxylic or sulfonic acids or trimethylalkylammonium moieties) onto the heteroaryl scaffold, leading to cyan-green emitting coumarins that were both water-soluble and strongly fluorescent under physiol. conditions. The further extension of this condensation reaction to bis(2-aminophenyl)diselenide enabled the first synthesis of 3-(2-benzoselenazolyl)-7-hydroxycoumarin. The potential utility of these new 7-hydroxycoumarins was demonstrated through the synthesis and spectroscopic and analyte-responsive behavior of fluorogenic probes suitable for sensing biol. relevant thiols and urokinase, a protease that plays a key role in cancer invasion and metastasis. A fluorescence probe for urokinase-type plasminogen activator (uPA, peptidolytic urokinase which is a biomarker for breast cancer, mammary gland neoplasm) was developed and the synthesis of the target compound was achieved by attaching N-acetyl-3-[(1,1-dimethylethyl)dithio]-
European Journal of Organic Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia