Wen, Tingyu published the artcileDiscovery, semisynthesis and neurite outgrowth-promoting activity of novel merrillianone/cycloparvifloralone based esters as neurotrophic agents, Application of 3-Benzoylpropionicacid, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127832, database is CAplus and MEDLINE.
Natural products (NPs) are very important sources for the development of new drugs. Merrillianone and cycloparvifloralone, isolated from the roots, stems, and fruits of Illicium henryi Diels, are two natural sesquiterpene compounds In continuation of our effort to discover more effective neurotrophic compounds from NPs, a series of novel merrillianone/cycloparvifloralone based esters I (R = MeCH:CHCH:CH, CH2CH2Ph, CH2CH2COPh, etc.) and II (R = 4-BrC6H4CH2, 2-naphthylmethyl, CH:CHPh, etc.) were prepared and their structures were characterized by 1H NMR, 13C NMR and IR spectral analyses. Furthermore, the spatial structure of compound I (R = CH2CH2Ph) was unambiguously confirmed by X-ray crystallog. The neurite outgrowth-promoting activity results indicated that most of the target derivatives exhibited more potent neurite outgrowth-promoting activity than merrillianone and cycloparviforalone. Among all target derivatives, the neurite outgrowth-promoting activity of compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CHMe, 4-FC6H4CH2CH2) was about 2-fold stronger than that of their precursors merrillianone and cycloparvifloralone, resp. Besides, compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CH) displayed relatively low cytotoxicity to normal GES-1 cells. Moreover, these derivatives had good hydrolytic stability. Finally, some interesting results of the structure-activity relationships (SARs) were also discussed. This work will pave the way for the development of merrillianone/cycloparvifloralone derivatives as potential neurotrophic agents.
Bioorganic & Medicinal Chemistry Letters published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C8H8O2, Application of 3-Benzoylpropionicacid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia