Bennett, Jeffrey A. published the artcileContinuous Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in a Cartridge Flow Reactor Using a Gel-Supported Catalyst, Safety of 4,4′-Dimethyldiphenyl, the publication is Industrial & Engineering Chemistry Research (2021), 60(26), 9418-9428, database is CAplus.
The Suzuki-Miyaura cross-coupling reaction is one of the most important reactions for pharmaceutical and fine chem. synthesis, performed using both homogeneous and heterogeneous catalysis. In this work, we crosslink poly(methylhydrosiloxane) (PMHS) with tri(ethylene glycol divinyl ether) to create a versatile and readily accessible gel catalyst support for Suzuki-Miyaura cross-coupling reactions in a pseudoheterogeneous manner. The Si-H units present on the PMHS backbone act dually as the crosslinking site and the reducing agent to anchor and reduce palladium(II) acetate to active palladium(0). The PMHS-supported Pd catalyst is then packed into a stainless-steel flow reactor to create a cartridgelike reactor for the continuous operation of a model Suzuki-Miyaura cross-coupling reaction. We systematically investigate the role of reaction temperature, catalyst loading, crosslinking d., and gel particle size on the transient and steady-state behavior of the cartridge flow reactor through an automated flow chem. platform. The PMHS-supported catalytic particles demonstrate minimal deactivation and leaching over a continuous (80 h) Suzuki-Miyaura cross-coupling reaction at a 30 min nominal residence time at a relatively high reaction temperature of 95¡ãC. The developed modular flow chem. strategy equipped with the cartridge flow reactor enables accelerated studies of the fundamental and applied characteristics of gel-supported catalysts while providing increased safety, higher throughput, and removal of the separation step needed for catalyst recovery compared to homogeneous cross-coupling reactions in batch reactors.
Industrial & Engineering Chemistry Research published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C14H14, Safety of 4,4′-Dimethyldiphenyl.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia