Organic & Biomolecular Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Category: catalysis-chemistry.
Castillo Melean, Johnny published the artcileEnantiospecific synthesis of 2-[18F]fluoro-L-phenylalanine and 2-[18F]fluoro-L-tyrosine by isotopic exchange, Category: catalysis-chemistry, the publication is Organic & Biomolecular Chemistry (2011), 9(3), 765-769, database is CAplus and MEDLINE.
2-[18F]Fluoro-L-phenylalanine and 2-[18F]fluoro-L-tyrosine have been developed as promising radiopharmaceuticals for mol. imaging using positron emission tomog. (PET). However, the lack of a convenient radiosynthetic pathway has limited their practical use. In this work a new three-step nucleophilic synthesis of these compounds starting from [18F]fluoride is described. Corresponding precursors (I) (R1 = H or OCH2Ph; Boc = tert-butoxycarbonyl) were 18F-fluorinated by isotopic exchange, followed by the removal of an activating formyl group with Rh(PPh3)3Cl and subsequent hydrolysis of protecting groups in acidic medium. All reactions were carried out using both conventional and microwave heating. Conventional heated reactions yielded the desired products 2-[18F]Fphe and 2-[18F]Ftyr in 43% and 49% whereas radiochem. yields of 34% and 43%, resp., were obtained when they were heated by microwaves. Under optimized conditions the enantiomeric purity was ¡Ý94% for both radiopharmaceuticals.
Organic & Biomolecular Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia