Csiba, I. published the artcileOrganic ammonium salts. XV. Preparation and antimicrobial activity of alkylammonium salts of 2-(N,N-dimethylamino)-esters of benzoic, phenylacetic and phenoxyacetic acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Cesko-Slovenska Farmacie (1986), 35(2), 61-7, database is CAplus.
The preparation of 22 new organic ammonium unsubstituted salts and p–tert-Bu substituted benzoyl-, phenylacetyl-, and phenoxyacetyloxyethylalkyldimethylammonium bromides and alkyldimethyl-p–tert-butylbenzylammonium bromides is reported, where the linear alkyl chain (R) has 8-16 C atoms. Besides the preparation of the above-mentioned compounds, soft analogs of hard antimicrobially active benzalkonium salts were investigated for the influence of structural changes on the antimicrobial activity, expressed as the min. inhibitory concentration (MIC). The test strains included Staphylococcus?aureus, Escherichia?coli and Candida?albicans. A change in the length of the alkyl chain influenced the activity against E. coli only, the course of the dependence MIC = f(R) was nonlinear, and maximum effectiveness was achieved in decyl and dodecyl derivatives This structural change did not principally influence the activity against S. aureus and C. albicans. The presence of the p–tert-Bu group in the mol. enhanced the activity against S. aureus and C. albicans, the introduction of the ester group into the mol. decreased the activity against E. coli. Interruption of the conjugation of the aromate by the CH2 and the O-CH2 bridge decreased the activity against E. coli; the effectiveness against S. aureus and C. albicans was not markedly changed. In comparison with the hard analog Ajatin (benzyldodecyldimethylammonium bromide) the compounds under study were more effective and comparable to Septonex (N-[1-(ethoxycarbonyl)pentadecyl]trimethylammonium bromide) in all 3 microorganisms tested. The proposed products of hydrolytic degradation of the compounds with an ester group show a low (dodecyl-2-hydroxyethyldimethylammonium bromide) or negligible (the pertinent substituted and unsubstituted acids) antimicrobial activity and from this point of view the studied ammonium salts with an ester group in the mol. can be classed into the category of soft antimicrobially effective compounds
Cesko-Slovenska Farmacie published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.
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https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia