Hamdy, Rania published the artcileDesign, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting Bcl-2, Product Details of C12H16O3, the publication is International Journal of Molecular Sciences (2020), 21(23), 8980, database is CAplus and MEDLINE.
A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles I [R = benzyl, 4-methylphenoxymethyl, 4-nitrophenyl, etc.] were designed, synthesized and tested in-vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on previously reported compounds Synthesis of the target 1,3,4-oxadiazoles I were readily accomplished through a cyclization reaction of indole carboxylic acid hydrazide with substituted carboxylic acid derivatives RC(O)OH in the presence of phosphorus oxychloride. New compounds I showed a range of IC50 values concentrated in the low micromolar range selectively in Bcl-2 pos. human cancer cell lines. The most potent candidate I [R = 4-trifluorophenyl] showed selective IC50 values of 0.52-0.88¦ÌM against Bcl-2 expressing cell lines with no inhibitory effects in the Bcl-2 neg. cell line. Moreover, I [R = 4-trifluorophenyl] showed binding that was two-fold more potent than the pos. control gossypol in the Bcl-2 ELISA binding affinity assay. Mol. modeling studies helped to further rationalize anti-apoptotic Bcl-2 binding and identified compound I [R = 4-trifluorophenyl] as a candidate with drug-like properties for further investigation as a selective Bcl-2 inhibitory anticancer agent.
International Journal of Molecular Sciences published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Product Details of C12H16O3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia