Khan, Abida’s team published research in Drug Development Research in 81 | CAS: 2051-95-8

Drug Development Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Name: 3-Benzoylpropionicacid.

Khan, Abida published the artcileSynthesis of novel N-substitutedphenyl-6-oxo-3-phenylpyridazine derivatives as cyclooxygenase-2 inhibitors, Name: 3-Benzoylpropionicacid, the publication is Drug Development Research (2020), 81(5), 573-584, database is CAplus and MEDLINE.

The novel non-ulcerogenic N-substituted-phenyl-6-oxo-3-phenylpyridazine derivatives such as I [X = NNHC(S)NH2, NNHC(S)NHPh, NNHC(O)CH2CN, NNHPh] and II [R1 = NH2, CH2CN, CH2C(O)NH2, etc.] were synthesized by the reaction of 4-(6-oxo-3-phenylpyridazin-1[6H]-yl)benzaldehyde I [X = O] with different hydrazines or thiazolidin-4-ones. The novel aldehyde I [X = O] was prepared by reacting 6-phenylpyridazin-3(2H)-one with 4-fluorobenzaldehyde. Compounds I [X = NNHC(S)NH2, NNHC(S)NHPh, NNHPh] and compound II [R1 = NH2] were assessed for their anti-inflammatory potential and gastric ulcerogenic effects. The mol. docking investigations of compounds I [X = NNHC(S)NH2, NNHC(S)NHPh, NNHPh] and compound II [R1 = NH2] were also undertaken. The compounds I [X = NNHC(S)NH2] (IC50 = 17.45 nm; p < .05), I [X = NNHC(S)NHPh] (IC50 = 17.40 nm; p < .05), I [X = NNHPh] (IC50 = 16.76 nm; p < .05), and II [R1 = NH2] (IC50 = 17.15 nm; p < .05) displayed better COX-2 inhibitory activity than celecoxib (IC50 = 17.79 nm; p < .05). The compounds I [X = NNHC(S)NHPh, NNHPh] and II [R1 = NH2] revealed no gastric ulcerogenic effects, wherein the compound I [X = NNHC(S)NH2] produced almost negligible gastric ulcerogenic effects than celecoxib and indomethacin. All synthesized compounds such as I and II were evaluated for COX-1/COX-2 inhibition assay, among which compounds I [X = NNHC(S)NH2, NNHC(S)NHPh, NNHPh] and compound II [R1 = NH2] were identified as potent and safe non-ulcerogenic COX-2 inhibitors.

Drug Development Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Name: 3-Benzoylpropionicacid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia