Lobe, Maloba M. M. published the artcile3′,4′-Dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is Royal Society Open Science (2020), 7(1), 191316, database is CAplus and MEDLINE.
In the present study, 3′,4′-dihydro-2’H-spiro[indoline-3,1′-isoquinolin]-2-ones, designed as mol. hybrids of THIQ and OX, were synthesized and screened in-vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents.
Royal Society Open Science published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia