MacLean, Mark A. published the artcileDiversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(1), 100-104, database is CAplus and MEDLINE.
N-Aryl derivatives of edaravone were identified as potentially effective small mol. inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer’s disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochem. assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.
Bioorganic & Medicinal Chemistry Letters published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C30H42NOP, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia