Roos, Casey B. published the artcileEnantioselective Hydroamination of Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer, Recommanded Product: 2,4,6-Triisopropylbenzenethiol, the publication is Journal of the American Chemical Society (2020), 142(13), 5974-5979, database is CAplus and MEDLINE.
An enantioselective, radical-based method for the intramol. hydroamination of alkenes with sulfonamides to afford pyrrolidines I [R1 = Ph, 2-thienyl, 2,4,6-tri-MeC6H2, etc.; R2 = H, Me; R3 = Me, t-Bu, CH2CH2CH=CMe2; R2R3 = (CH2)2, (CH2)5, CH2CH2NBocCH2CH2] was reported. These reactions were proposed to proceed via N-centered radicals formed by proton-coupled electron transfer (PCET) activation of sulfonamide N-H bonds. Noncovalent interactions between the neutral sulfonamidyl radical and a chiral phosphoric acid generated in the PCET event were hypothesized to serve as the basis for asym. induction in a subsequent C-N bond forming step, achieving selectivities of up to 98:2 er. These results offer further supported for the ability of noncovalent interactions to enforce stereoselectivity in reactions of transient and highly reactive open-shell intermediates.
Journal of the American Chemical Society published new progress about 22693-41-0. 22693-41-0 belongs to catalysis-chemistry, auxiliary class Other Functionalization Reagent, name is 2,4,6-Triisopropylbenzenethiol, and the molecular formula is C15H24S, Recommanded Product: 2,4,6-Triisopropylbenzenethiol.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia