Tadros, Joseph published the artcileA Comparison of Immobilised Triphenylphosphine and 1-Hydroxybenzotriazole as Mediators of Catch-and-Release Acylation Under Flow Conditions, Safety of 2-Methylbenzoic acid, the publication is Chemistry – An Asian Journal (2022), 17(5), e202101308, database is CAplus and MEDLINE.
Herein, a comparative study of immobilized triphenylphosphine (PS-PPh3) and 1-hydroxybenzotriazole (PS-HOBt) to mediate amide couplings under continuous flow was described. Compared to Appel-type amidations (PS-PPh3), the developed ‘catch-and-release’ approach (PS-HOBt) afforded near-quant. amide conversions. Utilizing this strategy, sulfonyl chloride amenability enabled facile access to an expanded library of sulfonate and sulfonamides. Post-constructional peptide modification was also demonstrated, affording two N¦Â-functionalized pentapeptides in high yields and purities. In contrast to frequently utilized coupling agents, the PS-HOBt resin could be recycled six times without a reduction in efficacy or regeneration requirements.
Chemistry – An Asian Journal published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C15H21BO3, Safety of 2-Methylbenzoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia