Zlatopolskiy, Boris D. published the artcileDiscovery of 18F-JK-PSMA-7, a PET probe for the detection of small PSMA-positive lesions, Name: Tetraethylammonium hydrogencarbonate, the publication is Journal of Nuclear Medicine (2019), 60(6), 817-823, database is CAplus and MEDLINE.
The aim of this study was the development of highly selective and specific PSMA probes with enhanced imaging properties, in comparison with 18FDCFPyL, 18F-PSMA-1007, and 68Ga-PSMA-11. Methods: Eight novel 18F-labeled PSMA ligands were prepared Their cellular uptake in PSMA-pos. LNCaP C4-2 and PSMA-neg. PC-3 cells was compared with that of 18F-DCFPyL. The most promising candidates were addnl. evaluated by small-animal PET in healthy rats using PSMA-pos. peripheral ganglia as a model for small PCa lesions. PET images of the ligand with the best outcome, 18F-JKPSMA- 7, were compared with those of 18F-DCFPyL, 18F-PSMA-1007, and 68Ga-PSMA-11 with respect to key image-quality parameters for the time frame 60-120 min. Results: Compared with 18F-DCFPyL, 18FJK- PSMA-7 demonstrated increased PSMA-specific cellular uptake. Although target-to-background ratios of 18F-DCFPyL and 18F-PSMA- 1007 were comparable, this parameter was higher for 18F-JK-PSMA- 7 and lower for 68Ga-PSMA-11. Image acutance was significantly higher for 18F-JK-PSMA-7 and 18F-PSMA-1007 than for 18F-DCFPyL and 68Ga-PSMA-11. Conclusion: 18F-JK-PSMA-7 is a promising candidate for high-quality visualization of small PSMApos. lesions.
Journal of Nuclear Medicine published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C14H12O2, Name: Tetraethylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia