Amici, Giuseppe published the artcileEffect of hypocholesterolemic substances on lipid content in organs of rats on a high fat diet, Recommanded Product: 2-Methyl-4-phenylbutanoic acid, the publication is Minerva Medica (1966), 57(96), 4056-64, database is CAplus and MEDLINE.
Groups of 10 rats were fed the following diets: (1) standard pellets and H2O; (2) diet 1 with phenylethylacetic acid or ¦Á-phenylbutyric acid (I) (700 mg./kg./24 hrs.); (3) excess lipid-containing diet; (4) diet 3 with I; (5) diet 3 with ¦Â-benzal butyramide (II) (260 mg./kg./24 hrs.); (6) diet 3 with ¦Á-methyl-¦Ã-phenylbutyric acid (III) (260 mg./kg./24 hrs.). Five rats in each group were examined after 20 days and 5 after 40 days on the diets. Body weight, total blood cholesterol (TBC); wet and dry weight of liver, lungs, testes, adrenals, and aorta, and their content of total fatty acids (TFA), total cholesterol (TC), esterified cholesterol (EC), free cholesterol (FC), and phospholipids (PL) was determined Cholesterol-lowering compounds decreased TC and EC in all examined organs under the conditions of diet 2. An initial increase in TFA was followed by a decrease below control levels. PL increased in the liver, lungs, and testes and decreased in the adrenals and aorta. Diets 4, 5, and 6 inhibited the increase in TFA, TC, EC, and PL levels in the liver, lungs, and the aorta. TBC, body weight, and wet and dry weight increases induced by diet 3 were also inhibited by diets, 4, 5, and 6. The effects were particularly marked with diet 5, where TFA, TC, and EC levels lower than control values under diet 1 were observed. Response to diet 3 was different in the testes and adrenals than in other organs: dry and wet weight did not increase, TC and EC decreased and TFA increased less than elsewhere. PL decreased in the adrenals and increased slightly in the testes. I, II, and III inhibited the increase in TFA levels of testes and adrenals, but did not decrease the TC and EC levels, which were found instead to be relatively higher. It is suggested that I, II, and III (II being the more potent) are particularly effective in decreasing the TFA, TC, and EC content of the liver, lungs, and aorta, i.e. the organs where the deposition of exogenous lipids selectively occurs. 57 references.
Minerva Medica published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C11H14O2, Recommanded Product: 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia