Dai, Yumin published the artcileIsolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure-activity relationships of related compounds, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry (2014), 22(1), 269-276, database is CAplus and MEDLINE.
Bioassay-guided separation of the South African plant Kniphofia ensifolia for antiplasmodial activity led to the isolation of two new anthraquinones, named kniphofiones A and B, I [R = COC6H4OH-4, (E)-COCH:CHC6H4OH-4, resp.], together with three known bioactive anthraquinone monomers, and four known bisanthraquinones. The structures of the two new compounds were elucidated based on analyses of their 1D and 2D NMR spectra and mass spectrometric data. The dimeric compounds II (R1 = H, OH) displayed the strongest antiplasmodial activity among all the isolated compounds, with IC50 values of 0.4 ¡À 0.1 and 0.2 ¡À 0.1 ¦ÌM, resp. The two new compounds displayed modest activities, with IC50 values of 26 ¡À 4 and 9 ¡À 1 ¦ÌM, resp. Due to the synthetic accessibility of the new compounds and the increased activity shown by the dimeric compounds, a structure-activity relationship study was conducted. As a result, one analog of kniphofione B, the caffeic acid derivative of aloe-emodin, I [R = (E)-COCH:CHC6H3(OMe)2-3,4], was found to have the highest activity among all the aloe-emodin derivatives, with an IC50 value of 1.3 ¡À 0.2 ¦ÌM.
Bioorganic & Medicinal Chemistry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia