Fairhurst, Robin A. published the artcileIdentification and optimization of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors, Synthetic Route of 6972-05-0, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(17), 3569-3574, database is CAplus and MEDLINE.
Exploring the affinity-pocket binding moiety of a 2-aminothiazole (S)-proline-amide-urea series of selective PI3K¦Á inhibitors using a parallel-synthesis approach led to the identification of a novel 4′,5-bisthiazole sub-series. The synthesis and optimization of both the affinity pocket and (S)-proline amide moieties within this 4′,5-bisthiazole sub-series are described. From this work a number of analogs, including (I) (A66) and (II), were identified as potent and selective PI3K¦Á inhibitor in vitro tool compounds
Bioorganic & Medicinal Chemistry Letters published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Synthetic Route of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia