Kim, Jaeseung published the artcileSilanediol Inhibitors of Angiotensin-Converting Enzyme. Synthesis and Evaluation of Four Diastereomers of Phe[Si]Ala Dipeptide Analogues, Safety of Difluorodiphenylsilane, the publication is Journal of Organic Chemistry (2005), 70(15), 5781-5789, database is CAplus and MEDLINE.
Phe-Ala silanediol dipeptide mimics I as four diastereoisomers [(S,S)-, (S,R)-, (R,R)- and (R,S)-I] have been evaluated as inhibitors of angiotensin-converting enzyme (ACE) and compared to ketone-based inhibitors II reported by Almquist et al. One stereogenic center of the isomers was derived from the individual enantiomers of Me 3-hydroxy-2-methylpropionate, with separation of diastereomers after introduction of the second stereogenic center. The diastereomeric identities were established by x-ray crystallog. of an intermediate. Inhibition of ACE by (S,S)-I, (R,R)-I, (R,S)-I diastereomers (IC50 = 3.8 – 207 nM) closely paralleled that of the corresponding diastereomeric ketones II (IC50 = 1.0 – 46 nM). (S,R)-I, corresponding to the least inhibitory ketone (IC50 = 3200 nM), exhibited an unexpected level of inhibition in the silanediol (IC50 = 72 nM), suggesting an alternative mode of binding to the enzyme.
Journal of Organic Chemistry published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Safety of Difluorodiphenylsilane.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia