Kuroda, Tokuyuki published the artcileSynthesis and biological activity of novel mitomycin C analogs derived from mitomycin A, Related Products of catalysis-chemistry, the publication is Journal of Heterocyclic Chemistry (1994), 31(1), 113-19, database is CAplus.
A variety of mitomycin C analogs were synthesized from mitomycin A and their biol. activities were studied. Mitomycin A (I) underwent nucleophilic displacement reactions involving intramol. hydrogen migrations upon treatment with nitrogen nucleophiles bearing mobile hydrogens, but the mode of hydrogen migration depended on the nature of the nucleophiles. The reaction with alkoxyamines gave oximes II (R = Me, CH2CHMe2). However, the reaction with hydroxylamine and benzohydrazine afforded imines III (R1 = OH, NHBz). These products were converted into various types of mitomycin C derivatives by methylation with Me iodide or di-Me sulfate. The mechanistic features of these reactions are discussed. The in vitro and in vivo biol. activities were tested by using P388 leukemia and Sarcoma 180 tumor cells. Several of the synthesized compounds exhibited better activity than that of mitomycin C.
Journal of Heterocyclic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia