Laufer, Stefan published the artcileTri- and tetra-substituted imidazoles as p38¦Á mitogen-activated protein kinase inhibitors, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(22), 6671-6675, database is CAplus and MEDLINE.
The synthesis of 2,4,5-tri-substituted and 1,2,4,5-tetra-substituted imidazoles, e.g. I, as potent p38¦Á mitogen-activated protein kinase inhibitors is described. The tri-substituted imidazole series was found to be more potent than the tetra-substituted imidazole series. Many of these compounds show low-nanomolar activities in the isolated p38¦Á MAP kinase inhibition assay. The structure-activity relationships between these two series are different and not comparable.
Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia