Shiina, Isamu published the artcileEnantioselective total synthesis of Octalactin A using asymmetric aldol reactions and a rapid lactonization to form a medium-sized ring, Synthetic Route of 19117-31-8, the publication is Chemistry – A European Journal (2005), 11(22), 6601-6608, database is CAplus and MEDLINE.
Octalactin A (I), an antitumor agent (no data) containing an eight-membered lactone moiety, has been stereoselectively prepared by means of enantioselective aldol reactions of selected silyl enolates with achiral aldehydes, promoted by a chiral SnII complex. The medium-sized lactone part was effectively constructed by way of a new and rapid mixed-anhydride lactonization using 2-methyl-6-nitrobenzoic anhydride (MNBA) with a catalytic amount of 4-(dimethylamino)pyridine (DMAP) or 4-(dimethylamino)pyridine 1-oxide (DMAPO). The use of only 5 mol % of DMAP or 2 mol % of DMAPO rapidly promoted formation of the medium-sized ring of the octalactin, demonstrating the remarkable efficiency of the new lactonization protocol.
Chemistry – A European Journal published new progress about 19117-31-8. 19117-31-8 belongs to catalysis-chemistry, auxiliary class Oxidant, name is N-(tert-Butyl)-S-phenylthiohydroxylamine, and the molecular formula is C6H10O7, Synthetic Route of 19117-31-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia