Yun, Jisu published the artcilePalladium-Catalyzed ¦Á-Arylation of Cyclic ¦Â-Dicarbonyl Compounds for the Synthesis of CaV1.3 Inhibitors, Application of N1,N2-Dibenzylethane-1,2-diamine, the publication is ACS Omega (2022), 7(16), 14252-14263, database is CAplus and MEDLINE.
Cyclic ¦Á-aryl ¦Â-dicarbonyl derivatives are important scaffolds in medicinal chem. Palladium-catalyzed coupling reactions of haloarenes were conducted with diverse five- to seven-membered cyclic ¦Â-dicarbonyl derivatives including barbiturate, pyrazolidine-3,5-dione, and 1,4-diazepane-5,7-dione. The coupling reactions of various para- or meta-substituted aryl halides occurred efficiently when Pd(t-Bu3P)2, Xphos, and Cs2CO3 were used under 1,4-dioxane reflux conditions. Although the couplings of ortho-substituted aryl halides with pyrazolidine-3,5-dione and 1,4-diazepane-5,7-dione were moderate, the coupling with barbiturate was limited. Using the optimized reaction conditions, we synthesized several 5-aryl barbiturates as new scaffolds of CaV1.3 Ca2+ channel inhibitors. Among the synthesized mols., I was the most potent CaV1.3 inhibitor with an IC50 of 1.42¦ÌM.
ACS Omega published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C4H5F3N2O3S, Application of N1,N2-Dibenzylethane-1,2-diamine.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia