Zhuang, Zhe published the artcileRapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C-H/C-H Coupling: Four-Step Total Synthesis of (¡À)-Russujaponol F, Name: 2-Methyl-4-phenylbutanoic acid, the publication is Journal of the American Chemical Society (2021), 143(2), 687-692, database is CAplus and MEDLINE.
The development of practical C-H/C-H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C-C bonds. Herein we report a cyclative C(sp3)-H/C(sp2)-H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected ¦Â-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na2CO3¡¤1.5H2O2) as the sole oxidant and generates water as the only byproduct. A range of biol. important scaffolds, including tetralins, chromans, and indanes, can be easily prepared by this protocol. Finally, the synthetic application of this methodol. is demonstrated by the concise total synthesis of (¡À)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through sequential functionalizations of four C-H bonds.
Journal of the American Chemical Society published new progress about 1949-41-3. 1949-41-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene, name is 2-Methyl-4-phenylbutanoic acid, and the molecular formula is C7H8BFO2, Name: 2-Methyl-4-phenylbutanoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia