Abraham, D. J.’s team published research in Journal of Medicinal Chemistry in 27 | CAS: 1798-04-5

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Abraham, D. J. published the artcileDesign, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid, the publication is Journal of Medicinal Chemistry (1984), 27(8), 967-78, database is CAplus and MEDLINE.

The title compounds I (R1 = O, S, CH2O, CH2S, or CH2OCH2; R2 = H, Br, Cl, F, Me, or MeO; R3 = H, Cl, F, Me, or MeO; R4 = H, Br, Cl, Me, NH2, etc.; R5 = H, Cl, F, Me, or MeO; R6 = H, Br, Cl, F, or Me; R7 and R8 = H or Me) and miscellaneous compounds were prepared and evaluated in vitro for antigelling activity. 2-[(p-Bromophenoxy)ethyl]malonic?acid (II) [90296-21-2] was the most active compound A hypothesis about a mechanism to explain their effects on the O equilibrium properties of Hb is given. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Name: 2-(4-(tert-Butyl)phenoxy)acetic acid.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia