Basinger, Mark A.’s team published research in Research Communications in Chemical Pathology and Pharmacology in 30 | CAS: 38260-01-4

Research Communications in Chemical Pathology and Pharmacology published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Basinger, Mark A. published the artcileRelative efficacy of chelating agents as antidotes for acute nickel(II) acetate intoxication, HPLC of Formula: 38260-01-4, the publication is Research Communications in Chemical Pathology and Pharmacology (1980), 30(1), 133-41, database is CAplus and MEDLINE.

The relative efficacy of 14 chelating agents in alleviating acute Ni(OAc)2 [373-02-4] (i.p.) intoxication was determined The LD50 for i.p. Ni(OAc)2 in mice was 45.7 mg/kg with a 95% confidence limit of 39.2-53.3 mg/kg. With 62 mg Ni(OAc)2/kg (i.p.) (i.e. ¡ÝLD90), the most effective antidotes were D-penicillamine [52-67-5] and Na2CaEDTA [62-33-9]. The acetylation of the NH2 group in penicillamine to give N-acetyl-D,L-penicillamine [59-53-0] effectively destroys the antidotal action, as would be expected if coordination to the N were essential to the process.

Research Communications in Chemical Pathology and Pharmacology published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, HPLC of Formula: 38260-01-4.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia