Kouchi, Zen published the artcileFunction of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis, SDS of cas: 63-68-3, the publication is Scientific Reports (2022), 12(1), 4325, database is CAplus and MEDLINE.
Recent investigations of neurol. developmental disorders have revealed the Rho-family modulators such as Syde and its interactors as the candidate genes. Although the mammalian Syde proteins are reported to possess GTPase-accelerating activity for RhoA-family proteins, diverse species-specific substrate selectivities and binding partners have been described, presumably based on their evolutionary variance in the mol. organization. A comprehensive in silico anal. of Syde family proteins was performed to elucidate their mol. functions and neurodevelopmental networks. Predicted structural modeling of the RhoGAP domain may account for the mol. constraints to substrate specificity among Rho-family proteins. Deducing conserved binding motifs can extend the Syde interaction network and highlight diverse but Syde isoform-specific signaling pathways in neuronal homeostasis, differentiation, and synaptic plasticity from novel aspects of post-translational modification and proteolysis.
Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, SDS of cas: 63-68-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia