Lee, Jee-Hyun published the artcileSynthesis and evaluation of (+)-decursin derivatives as inhibitors of the Wnt/¦Â-catenin pathway, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(15), 3529-3532, database is CAplus and MEDLINE.
We synthesized (+)-decursin derivatives substituted with cinnamoyl- and Ph propionyl groups originating from (+)-CGK062 and screened them using a cell-based assay to detect relative luciferase reporter activity. Of this series, compound I, in which a 3-acetoxy cinnamoyl group was introduced, most potently inhibited (97.0%) the Wnt/¦Â-catenin pathway. Specifically, compound I dose-dependently inhibited Wnt3a-induced expression of the ¦Â-catenin response transcription (CRT) and increased ¦Â-catenin degradation in HEK293 reporter cells. Furthermore, compound I suppressed expression of the downstream ¦Â-catenin target genes cyclin D1 and c-myc and suppressed PC3 cell growth in a concentration-dependent manner.
Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Application of (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia