Lupp, Amelie published the artcileIn vitro investigations on the interactions of different fomocaine metabolites with rat microsomal cytochrome P450, HPLC of Formula: 31719-76-3, the publication is Nova Acta Leopoldina (2003), 87(329), 253-264, database is CAplus.
Fomocaine is an ether-type local anesthetic used in dermatol. practice for surface anesthesia. In view of possible new (systemic) applications, e.g. in the therapy of migraine or as an antiarrhythmic, knowledge of interactions also of its metabolites with the cytochrome P 450 system and thus with the metabolism of endogenous or other foreign substances is of importance. Thus, in the present study effects of thirteen fomocaine metabolites on liver P 450 mediated monooxygenase functions were assessed by measuring the influence on the model reactions ethoxyresorufin O-deethylation, ethoxycoumarin O-deethylation, pentoxyresorufin O-depentylation and ethylmorphine N-demethylation. Possible (potentially beneficial) antioxidative capacities of the compounds were evaluated by the influence on luminol and lucigenin amplified chemiluminescence, H2O2 production, and stimulated lipid peroxidation in rat liver microsomes and on rat whole blood chemiluminescence. Fomocaine inhibited all four model reactions for P 450 mediated monooxygenase functions in micromolar concentrations In general, the effects of the metabolites were much less pronounced than those of fomocaine. Only 2-hydroxyfomocaine yielded similar effects as fomocaine. A noticeable inhibition of the model reactions was also seen with 4-hydroxyfomocaine. This effect was, however, already distinctly less than that of fomocaine. The overall antioxidative capacity of fomocaine was not very pronounced. Many of the metabolites, especially those containing a phenolic group, displayed a stronger antioxidative capacity than fomocaine. Again, effects were most pronounced with 2-hydroxy- and 4-hydroxyfomocaine. Considering all effects of the metabolites tested, it is to be expected that after systemic application biotransformation of fomocaine to these metabolites will lead to a decrease in the overall interactions with the P 450 system and to an increase in the antioxidative capacity on the whole.
Nova Acta Leopoldina published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, HPLC of Formula: 31719-76-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia