Narayanam, Maruthi Kumar published the artcilePositron emission tomography tracer design of targeted synthetic peptides via 18F-sydnone alkyne cycloaddition, SDS of cas: 17351-61-0, the publication is Bioconjugate Chemistry (2021), 32(9), 2073-2082, database is CAplus and MEDLINE.
Chem. synthesized, small peptides that bind with high affinity and specificity to CD8-expressing (CD8+) tumor-infiltrating T cells, yet retain the desirable characteristics of small mols., hold valuable potential for diagnostic mol. imaging of immune response. Here, we report the development of 18F-labeled peptides targeting human CD8¦Á with nanomolar affinity via the strain-promoted sydnone-alkyne cycloaddition with 4-[18F]fluorophenyl sydnone. The 18F-sydnone is produced in one step, in high radiochem. yield, and the peptide labeling proceeds rapidly. A hydrophilic chem. linker results in a tracer with favorable pharmacokinetic properties and improved image contrast, as demonstrated by in vivo PET imaging studies.
Bioconjugate Chemistry published new progress about 17351-61-0. 17351-61-0 belongs to catalysis-chemistry, auxiliary class Phase Transfer Catalyst, name is Tetraethylammonium hydrogencarbonate, and the molecular formula is C9H21NO3, SDS of cas: 17351-61-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia