Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, COA of Formula: C17H37NO3.
Ni, Feng published the artcileRemarkably Stereospecific Utilization of ATP ¦Á,¦Â-Halomethylene Analogues by Protein Kinases, COA of Formula: C17H37NO3, the publication is Journal of the American Chemical Society (2017), 139(23), 7701-7704, database is CAplus and MEDLINE.
ATP analogs containing a CXY group in place of the ¦Á,¦Â-bridging oxygen atom are powerful chem. probes for studying ATP-dependent enzymes. A limitation of such probes has been that conventional synthetic methods generate a mixture of diastereomers when the bridging carbon substitution is nonequivalent (X ¡Ù Y). We report here a novel method based on derivatization of a bisphosphonate precursor with a D-phenylglycine chiral auxiliary that enables preparation of the individual diastereomers of ¦Á,¦Â-CHF-ATP and ¦Á,¦Â-CHCl-ATP, which differ only in the configuration at the CHX carbon. When tested on a dozen divergent protein kinases, these individual diastereomers exhibit remarkable diastereospecificity (up to over 1000-fold) in utilization by the enzymes. This high selectivity can be exploited in an enzymic approach to obtain the otherwise inaccessible diastereomers of ¦Á,¦Â-CHBr-ATP. The crystal structure of a tyrosine kinase Src bound to ¦Á,¦Â-CHX-ADP establishes the absolute configuration of the CHX carbon and helps clarify the origin of the remarkable diastereospecificity observed We further synthesized the individual diastereomers of ¦Á,¦Â-CHF-¦Ã-thiol-ATP and demonstrated their utility in labeling a wide spectrum of kinase substrates. The novel ATP substrate analogs afforded by these two complementary strategies should have broad application in the study of the structure and function of ATP-dependent enzymes.
Journal of the American Chemical Society published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, COA of Formula: C17H37NO3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia