Ryan, Michael C. published the artcilePiperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones, Related Products of catalysis-chemistry, the publication is ACS Medicinal Chemistry Letters (2022), 13(4), 546-553, database is CAplus and MEDLINE.
While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement, we discovered that diamine-treated, 2-dihalomethylquinolinones unexpectedly afforded ring-expanded piperazine-fused benzodiazepinones I [R1 = NO2, F, CN; R2 = H, NO2; R3 = H, Br, 2-morpholinyl, etc.; R4 = Me, Bn; R5 = Me, cyclohexyl, Bn; Ar = Ph, 4-MeOC6H4, 4-FC6H4, etc.]. Notably, this new chemotype showed potent, submicromolar inhibition of virus-induced cell death, >7-log reduction of viral yield, and tractable structure-activity relationships across both viruses. Antiviral activity was confirmed in primary human neuronal cells. A mechanistic rationale for product formation is proposed, and key structural elements were comparatively modeled between a similarly substituted antiviral amidine and piperazinobenzodiazepinone prototypes to guide future antiviral development.
ACS Medicinal Chemistry Letters published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia