Thakral, Sumit published the artcile2′-Aryl-2,5′-bibenzoxazoles: Synthesis, crystal structure and evaluation of cytotoxicity against cervical (HeLa) and liver (HepG2) cancer cell lines, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2022), 133386, database is CAplus.
A library of twenty-four 2′-aryl-2,5′-bibenzoxazoles I [R1 = H, Me, OH; R2 = H, Me; R3 = H, Me, F, Cl, Br; R4 = H, Me; R5 = H, Cl] had been synthesized from 2-arylbenzoxazole-5-carboxylic acids which in turn were obtained by hydrolysis of Me 2-arylbenzoxazole-5-carboxylates in excellent yields. These carboxylates were prepared form Me 3-amino-4-hydroxybenzoate and readily available various benzoic acids. The bibenzoxazoles were characterized using NMR, FT-IR and HRMS techniques and the structure of compound I [R1 = OH; R2 = R3 = R4 = R5 = H] was established by X-ray crystallog. All the synthesized compounds were screened for cytotoxicity (in vitro) against cervical cancer (HeLa) and hepato-carcinoma (HepG2) cell lines and non-cancerous (HEK293) cell line. Compounds, I [R1 = H, Me, OH; R2 = H, Me; R3 = H, F, Br; R4 = R5 = H] showed good activity against HeLa cancer lines having the IC50 values 4.787, 9.611 and 10.68¦ÌM, resp.
Journal of Molecular Structure published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C11H22N2O4, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia