Watkins, John B. published the artcileCholeretic effect of structural analogs of valproic acid in the rat, Product Details of C10H20O2, the publication is Research Communications in Chemical Pathology and Pharmacology (1983), 39(3), 355-66, database is CAplus and MEDLINE.
A comparison of structure-choleretic activity relationship were made for several branched- and straight-chain carboxylic acids including valproic?acid??[99-66-1]. Cumulative bile flow was 13.8, 23.8, 29.4 and 14.9 mL/4h/kg for dimethyl- [79-31-2], diethyl- [88-09-5], dipropyl- (valproic acid), and dibutylacetic?acid??[3115-28-4], resp., after i.v. administration of approx. equimolar doses (1100 ¦Ìmoles/kg). Except for dibutylacetic acid, maximal bile flow increased from control rates of 50-60 to 120-140 ¦ÌL/min/kg. Administration of higher doses of 2,2-dimethylbutanoic?acid??[595-37-9] and 2-ethylbutanoic acid did not increase maximal bile flow above 125-140 ¦ÌL/min/kg but did prolong the duration of choleresis. Maximal and cumulative bile flows increased with length of carboxylic acid chain for 2,2-di-Me substituted acids (2,2-dimethylacetic?acid??[79-31-2] to 2,2-dimethylbutanoic acid). If the 2 Me groups were on C-3 (3-methylbutanoic?acid??[503-74-2]), no change in bile flow was observed Straight-chain acids from C-5 to C-11 and pent-4-enoic acid did not alter bile flow. Thus, the effectiveness of several branched-chain carboxylic acids as choleretics parallel their ability as anticonvulsants. In contrast, the straight-chain acids which cause central nervous system depression have no choleretic activity.
Research Communications in Chemical Pathology and Pharmacology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H11NO4, Product Details of C10H20O2.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia