Ahmed, Shamshad published the artcilePurines, pyrimidines, and imidazoles. Part XLIV. Syntheses of some dihydro-1,3-oxazine derivatives and related substituted uracils, COA of Formula: C3H8N2S, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1969-75, database is CAplus and MEDLINE.
The oxazinedione I (R = Me, R1 = R2 = H, X = O) (II) was prepared from MeCOCH2CO2Et by reaction with CO(NHR3)2 (R3 = Me, Et) in AcOH-Ac2O, or by heating with H2NCO2Et in the presence or absence of solvent. II was also prepared by heating MeCOCH2CONHR3 (III; R3 = CO2Et), or by heating III (R3 = CONMe2) with AcOH-Ac2O or H2SO4; its structure was confirmed by 1H and 13C NMR spectroscopy. Similar treatment of various ¦Â-oxo esters, including C-methyl and C-benzyl derivatives, with H2NCO2Et and with CO(NHMe)2 gave 6-aryl- and 6-alkyloxazinediones and 5,6-dialkyloxazinediones. E.g. 4-FC6H4COCH2CO2Et with CO(NHMe)2 in AcOH-Ac2O at reflux for 4 hr gave I (R = 4-FC6H4, R1 = R2 = H, X = O) whereas similar treatment of H2NCO2Et with MeCOCHMeCO2Et gave I (R = R1 = Me, R2 = H, X = O). Treatment of the oxazinediones I (X = O) with ammonia and with primary amines gave substituted uracils, whereas with secondary amines, acylated ureas were obtained. E.g. II with NH3, MeNH2, and NH2OH gave the corresponding substituted uracils I (R = Me, R1 = R2 = H, X = NH, NMe, NOH, resp.) and with H2NCH2CO2H, the acylated urea I (R = Me, R1 = R2 = H, X = NCH2CO2H) was obtained. II dimerized on heating with NaOH to give (6-hydroxy-4-methyl-2-pyridyl)acetic acid.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, COA of Formula: C3H8N2S.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia