Dai, Rongke published the artcileSynthesis of panaxadiol thiadiazole derivatives and study on its potential cell cycle arrest, Related Products of catalysis-chemistry, the publication is Journal of Molecular Structure (2022), 133208, database is CAplus.
In this study, panaxadiol (PD) derivs, I [R1 = 2-Me, 3-O2N, 3,4,5-trimethoxy, etc.] and II [R2 = H, AcO] were designed and synthesized by the reaction of thiadiazoles with PD. The identity of all final products I and II was elucidated by 1H, 13C NMR, HR-MS. The cytotoxicity activities of the derivatives I and II were evaluated against four cancer cell lines using the MTT assay which revealed they indicated excellent anticancer activity. Among these compounds, II [R2 = H] had the most significant cytotoxicity and distinctly inhibited the growth of a variety of tumor cells. Further studies showed that compound II [R2 = H] could decrease the expression levels of CDKs protein family and Cyclin D1 in A549, suggesting that compound II [R2 = H] could block the cell cycle. To prove the above conclusions, the binding sites of the two proteins were simulated by mol. docking method. The results demonstrated that the docking scores of II [R2 = H] and the two cyclins are higher than that of PD. Based on the complex of the target protein and ligand, it was speculated that the enhanced antiproliferative activity may be related to the increased hydrogen bonding interactions. Therefore, these data provide a reference that compound II [R2 = H] could be a promising lead drug for cancer treatment.
Journal of Molecular Structure published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia