Hu, Qi-Long published the artcileDemethylative alkylation of methionine residue by employing the sulfonium as the key intermediate, Application of Fmoc-Pro-OH, the publication is Organic Letters (2021), 23(21), 8543-8548, database is CAplus and MEDLINE.
Methionine (Met) offers a valuable handle to achieve peptide chem. modification owing to its unique thioether functional group. In contrast with cysteine, the site-selective functionalization of the hydrophobic and redox-sensitive thioether motif on peptides is still challenging, and strategies for diversification on the Met residue are rarely disclosed. Herein we report a transition-metal-free and redox-neutral approach for Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides.
Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Application of Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia