Li, Ren-Zhe published the artcileAsymmetric O-propargylation of secondary aliphatic alcohols, Safety of Difluorodiphenylsilane, the publication is Nature Catalysis (2020), 3(8), 672-680, database is CAplus.
Here, we report the development of a base-free, Cu-catalyzed propargylic substitution reaction that enables the efficient, asym. O-propargylation of secondary aliphatic alcs. Mechanistic studies implied key factors to slow down the undesired decomposition process of electrophiles in this reaction, which opened up the possibility of using secondary aliphatic alcs. as nucleophilic substrates. This asym. O-alkylation reaction proceeds under almost neutral conditions, tolerates a broad scope of functional groups and showed remarkable chemoselectivities. This method was amenable to the modification of natural products and com. drugs. The products obtained was readily elaborated to various classes of enantioenriched ¦Á,¦Á’-disubstituted ethers that were difficult to access by other methods.
Nature Catalysis published new progress about 312-40-3. 312-40-3 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is Difluorodiphenylsilane, and the molecular formula is C12H10F2Si, Safety of Difluorodiphenylsilane.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia