Lu, Guo-qing published the artcileDesign, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs, Name: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2019), 282-296, database is CAplus and MEDLINE.
Aryltriazolylphenylaminosulfonyl uracils such as I (R = Ph, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2-FC6H4, 3-FC6H4, 4-FC6H4, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4) were prepared as thymidylate synthase inhibitors for potential use as antitumor agents. The aryltriazolylphenylaminosulfonyl uracils were tested for their inhibition of human cancer cell lines and for their toxicities in normal human cell lines; selected compounds were tested for their inhibition of human thymidylate synthase (hTS). I (R = 4-ClC6H4) was the most effective antitumor agent of the compounds tested, inhibiting the growth of A549 cells with an IC50 value of 1.18 ¦ÌM and inhibiting hTS with an IC50 value of 0.13 ¦ÌM, superior to comparable data for the known antitumor agent pemetrexed. I (R = 4-ClC6H4) inhibited cell cycle advancement in G1/S phase and induced apoptosis. I (R = 4-ClC6H4) likely down-regulates the cycle checkpoint proteins cyclin D1 and cyclin E to inhibit cell cycle progression, and induced intrinsic apoptosis by activating caspase-3 and reducing the ratio of bcl-2 to bax.
European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Name: (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia