Ma, He published the artcileNew Cy5 photosensitizers for cancer phototherapy: A low singlet-triplet gap provides high quantum yield of singlet oxygen, SDS of cas: 104-03-0, the publication is Chemical Science (2021), 12(41), 13809-13816, database is CAplus and MEDLINE.
In the current work, a new strategy to enhance the singlet-triplet intersystem crossing (ISC) and high phototherapy efficiency was developed, based on the mol. design of a thio-pentamethine cyanine dye I [X = H, 4-MeOC6H4, 4-O2NC6H4, CHO, Q] (TCy5) as a photosensitizer. The introduction of an electron-withdrawing group at the meso-position of I could dramatically reduce the singlet-triplet energy gap (¦ÄEst) value (from 0.63 eV to as low as 0.14 eV), speed up the ISC process (¦ÓISC = 1.7 ps), prolong the lifetime of the triplet state (¦ÓT = 319¦Ìs) and improve singlet oxygen (1O2) quantum yield to as high as 99%, a value much higher than those of most reported triplet PSs. Further in vitro and in vivo experiments showed that I [X = CHO], with its efficient 1O2 generation and good biocompatibility, causes an intense tumor ablation in mice. This provided a new strategy for designing ideal photosensitizers for cancer phototherapy.
Chemical Science published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, SDS of cas: 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia