Sun, Juan published the artcileSynthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxane moiety as a novel class of potent methionine aminopeptidase type II inhibitors, Application In Synthesis of 1772-76-5, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 2876-2879, database is CAplus and MEDLINE.
A series of 1,3,4-oxadiazole derivatives containing 1,4-benzodioxane moiety have been designed, synthesized and evaluated for their antitumor activity. Most of the synthesized compounds were proved to have potent antitumor activity and low toxicity. Among them, compound I showed the most potent biol. activity against Human Umbilical Vein Endothelial cells, which was comparable to the pos. control. The results of apoptosis and flow cytometry (FCM) demonstrated that compound I induce cell apoptosis by the inhibition of MetAP2 pathway. Mol. docking was performed to position compound I into MetAP2 binding site in order to explore the potential target.
Bioorganic & Medicinal Chemistry Letters published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C10H9NO, Application In Synthesis of 1772-76-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia