Wang, Da-Wei published the artcileAn Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors, Computed Properties of 163839-73-4, the publication is Journal of Agricultural and Food Chemistry (2016), 64(47), 8986-8993, database is CAplus and MEDLINE.
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. To search for novel HPPD inhibitors, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using of N,N’-Carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were prepared in good to excellent yields. Some of the synthesized compounds displayed potent Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one (I) displayed high, broad-spectrum and post-emergent herbicidal activity at the rate of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, I showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that I might have the potential as herbicide for the weed control in maize and canola fields. I is the first HPPD inhibitor showing good crop safety towards canola.
Journal of Agricultural and Food Chemistry published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C15H12O8, Computed Properties of 163839-73-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia