Wu, Yunfei published the artcileSynthesis of novel 17-[3,6-dioxa-8-N-(substituted cinnamoyl)-octanediamino]-17-demethoxygeldanamycin derivatives, Related Products of catalysis-chemistry, the publication is Youji Huaxue (2014), 34(9), 1870-1874, database is CAplus.
Twenty six new 17-[3,6-dioxa-8-N-(substituted cinnamoyl)octanediamino]-17-demethoxygeldanamycins were designed, synthesized and evaluated for their cytotoxicities against growth of human breast cancer cell line MDA-MB-231 and binding affinities to heat shock protein 90 (Hsp90). Among these derivatives, 17-(3,6-dioxa-8-N-((E)-3-(3,5-dimethoxyphenyl)acrylamido)octanediamino)-17-demethoxygeldanamycin, was identified as the most potent one (IC50=1.5 ¦Ìmol/L, Kd=1.14 ¦Ìmol/L). Addnl., influence of substitutions at the cinnamoyl group on the bioactivities of this type of Geldanamycin (GA) derivatives was discussed. This study was anticipated to provide reference for the further structure modifications of GA for developing antitumor agents.
Youji Huaxue published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C8H10BNO3, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia