Xie, Yihui’s team published research in Organic Letters in 24 | CAS: 71989-31-6

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C6H8N2, Safety of Fmoc-Pro-OH.

Xie, Yihui published the artcileDevelopment of Fmoc-protected bis-amino acids toward automated synthesis of highly functionalized spiroligomers, Safety of Fmoc-Pro-OH, the publication is Organic Letters (2022), 24(18), 3421-3425, database is CAplus and MEDLINE.

We report the fluorenylmethoxycarbonyl (Fmoc) protection of functionalized bis-amino acid building blocks using a temporary Cu2+ complexation strategy, together with an efficient multikilogram-scale synthesis of bis-amino acid precursors. This allows the synthesis of stereochem. and functionally diverse spiroligomers utilizing solid-phase Fmoc/tBu (Fmoc = 9-fluorenylmethoxycarbonyl) chem. to facilitate the development of applications. Four tetramers were assembled on a semiautomated microwave peptide synthesizer. We determined their secondary structures with two-dimensional NMR spectroscopy.

Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C6H8N2, Safety of Fmoc-Pro-OH.

Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia