Zhang, Zhengxing published the artcileSynthesis and evaluation of 18F-labeled 4-nitrobenzyl derivatives for imaging tumor hypoxia with positron emission tomography: Comparison of 2-[18F]fluoroethyl carbonate and 2-[18F]fluoroethyl carbamate, Recommanded Product: Tetrabutylammonium hydrogencarbonate, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(2), 584-588, database is CAplus and MEDLINE.
Two 4-nitrobenzyl derivatives, 2-fluoroethyl 4-nitrobenzyl carbonate 1 and 4-nitrobenzyl N-2-fluoroethyl carbamate 2, were radiolabeled with 18F and evaluated for imaging tumor hypoxia with positron emission tomog. Although good tumor uptake was observed for [18F]1 and [18F]2 (>2.5%ID/g at 3-h post-injection), the tracers cleared slowly from nontarget tissues (>1.5%ID/g) and exhibited extensive defluorination in vivo (>4.0%ID/g for bone). Therefore, [18F]1 and [18F]2 are not suitable for imaging tumor hypoxia due to suboptimal tumor-to-background contrasts.
Bioorganic & Medicinal Chemistry Letters published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C18H23N3O4S, Recommanded Product: Tetrabutylammonium hydrogencarbonate.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia