Barolli, Joao P. published the artcileHeteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N’-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies, Product Details of C3H8N2S, the publication is Polyhedron (2017), 33-41, database is CAplus.
Ruthenium complexes were assessed as antitumor agents against cancer cells. In this project, new heteroleptic Ru(II) complexes [Ru(L)(bipy)(dppb)](PF6) (L = N,N-disubstituted-N’-acylthiourea, bipy = 2,2′-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane) were synthesized and characterized by elemental anal., IR and NMR (1H and 31P{1H}) spectroscopies, molar conductivity measurements and single crystal x-ray diffractometry. The IR and NMR data suggest the coordination of the ligands to the Ru(II) metal center through the thiocarbonyl and carbonyl groups. The structures of the new complexes were further studied by x-ray crystallog., which confirmed the coordination of the ligands with the metal through the S and O atoms, giving distorted octahedral complexes. The N,N-disubstituted-N’-acylthioureas and their complexes were screened with respect to their in vitro cytotoxicity. All compounds exhibited considerable antiproliferative activity against MCF-7 (human breast tumor cells ATCC HTB-26), DU-145 (human prostate tumor cells ATCC HTB-26), and relatively low toxicity against fibroblast L929 cells (health cell line from mouse ATCC CCL-1). A preliminary study regarding the mechanism of action of these compounds by confocal microscopy shows alterations of the actin filaments leading to modifications in cytoskeletal supporting the cell death and that the cell nucleus is not the main target of these complexes.
Polyhedron published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Product Details of C3H8N2S.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia