Herrera-Marcos, Luis V. published the artcileHepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model, Category: catalysis-chemistry, the publication is Scientific Reports (2022), 12(1), 1024, database is CAplus and MEDLINE.
Non-alc. fatty liver disease (NAFLD) is currently a growing epidemic disease that can lead to cirrhosis and hepatic cancer when it evolves into non-alc. steatohepatitis (NASH), a gap not well understood. To characterize this disease, pigs, considered to be one of the most similar to human exptl. animal models, were used. To date, all swine-based settings have been carried out using rare predisposed breeds or long-term experiments Herein, we fully describe a new exptl. swine model for initial and reversible NASH using cross-bred animals fed on a high saturated fat, fructose, cholesterol, cholate, choline and methionine-deficient diet. To gain insight into the hepatic transcriptome that undergoes steatosis and steatohepatitis, we used RNA sequencing. This process significantly up-regulated 976 and down-regulated 209 genes mainly involved in cellular processes. Gene expression changes of 22 selected transcripts were verified by RT-qPCR. Lipid droplet area was pos. associated with CD68, GPNMB, LGALS3, SLC51B and SPP1, and neg. with SQLE expressions. When these genes were tested in a second experiment of NASH reversion, LGALS3, SLC51B and SPP1 significantly decreased their expression. However, only LGALS3 was associated with lipid droplet areas. Our results suggest a role for LGALS3 in the transition of NAFLD to NASH.
Scientific Reports published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C5H11NO2S, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia