Pan, Yixiao published the artcileCobalt-Catalyzed Selective Transformation of Levulinic Acid and Amines into Pyrrolidines and Pyrrolidinones using Hydrogen, Computed Properties of 2051-95-8, the publication is Advanced Synthesis & Catalysis (2022), 364(16), 2830-2836, database is CAplus.
Cobalt-catalyzed selective transformation of levulinic acid and primary amines into pyrrolidines and pyrrolidinones under H2 was developed. The catalyst system consisting of Co(NTf2)2, 1,1,1-tris(di(4-methoxyphenyl)phosphinomethyl) ethane ((p-anisyl)triphos) and Me3SiOTf works well for the synthesis of pyrrolidines via reductive amination/cyclization/deoxygenative reduction of amide, and using Co(NTf2)2/1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) as the catalyst under reduced hydrogen pressure results in exclusive formation of pyrrolidinones. Both aryl and alkyl primary amines are suitable substrates, and a variety of functional groups are tolerated. Meanwhile, 4-oxo-4-arylbutanoic acids, 5-oxohexanoic acid, 6-oxoheptanoic acid, 2-formylbenzoic acid, 2-acetylbenzoic acid and 2¡ä-acetyl-[1,1¡ä-biphenyl]-2-carboxylic acid are also applicable, allowing for convenient access to cyclic amines and lactams with different ring size.
Advanced Synthesis & Catalysis published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Computed Properties of 2051-95-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia