Peterse, Evert published the artcileSolid-phase synthesis of macrocyclic peptides via side-chain anchoring of the ornithine ¦Ä-amine, Recommanded Product: Fmoc-Pro-OH, the publication is European Journal of Organic Chemistry (2022), 2022(11), e202101341, database is CAplus.
Cyclic peptides represent a popular class of macrocyclic drug candidates and therefore their solid phase synthesis has attracted much attention. In this contribution we present an efficient method of side-chain anchoring for ornithine and lysine residues to be used in the standard Fmoc-based (Fmoc = 9-fluorenylmethoxycarbonyl) synthesis of cyclic peptides via on-resin cyclization. We demonstrate that the side chain of ornithine and lysine protected with N-Boc-group (Boc = tert-butoxycarbonyl) can efficiently be converted to the isocyanate which is then immobilized on Wang-type resin in almost quant. yield. We further show the synthesis of four biol. active cyclic peptides employing the side chain ornithine anchoring. Our method is at least on a par with the previously reported methodologies in terms of yield and the purity of the final products and is arguably operationally more straightforward.
European Journal of Organic Chemistry published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia