Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1¦Á inhibitors, HPLC of Formula: 1798-04-5, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(4), 1453-1456, database is CAplus and MEDLINE.
A series of boron-containing phenoxyacetanilide derivatives I [R1 = BPin, B(OH)2; R2 = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1¦Á inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R1 = B(OH)2; R2 = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1¦Á accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 ¦ÌM). Compound II (GN26361) suppressed hypoxia-induced HIF-1¦Á accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1¦Á mRNA.
Bioorganic & Medicinal Chemistry Letters published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C5H5BO4S, HPLC of Formula: 1798-04-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia