Sun, Juan published the artcileAromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors, Application of (E)-3-(3-Nitrophenyl)acrylic acid, the publication is European Journal of Medicinal Chemistry (2014), 420-426, database is CAplus and MEDLINE.
A novel class of aromatic diacylhydrazine derivatives was designed as PLK1 inhibitors. All the 19 new synthesized compounds were assayed for antitumor activity against the resp. cervical cancer cells. In which, nine compounds with better antitumor activities were further tested for their PLK1 inhibitory activity. Last, we have successfully found that compound 7k showed both the promising antitumor activity with IC50 of 0.17 ¦ÌM against the cervical cancer cells, and also processed the most potent PLK1 inhibitory activity with IC50 of 0.03 ¦ÌM. In addition, docking simulation also carried out in this study to give a potent prediction binding mode between the small mol. and PKL1 (PDB code: 1umw) protein.
European Journal of Medicinal Chemistry published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C12H19BF2O3Si, Application of (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia