Ueda, Atsushi published the artcileE-Selective ring-closing metathesis in ¦Á-helical stapled peptides using carbocyclic ¦Á,¦Á-disubstituted ¦Á-amino acids, Related Products of catalysis-chemistry, the publication is Organic Letters (2022), 24(4), 1049-1054, database is CAplus and MEDLINE.
We present an E-selective ring-closing metathesis reaction in ¦Á-helical stapled peptides at positions i and i + 4. The use of two chiral carbocyclic ¦Á,¦Á-disubstituted ¦Á-amino acids, (1S,3S)-Ac5c3OAll and (1R,3S)-Ac5c3OAll, provides a high E-selectivity of a ¡Ü59:1 E:Z ratio, while mixtures with E:Z ratios of 2.1-0.5:1 were produced with standard acyclic (S)-(4-pentenyl)alanine amino acids. A stapled octapeptide composed of (1S,3S)- and (1R,3S)-Ac5c3OAll amino acids showed a right-handed ¦Á-helical crystal structure.
Organic Letters published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C3H5BN2O2, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia